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KMID : 0923620230230040033
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Immune Network
2023 Volume.23 No. 4 p.33 ~ p.33
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SARS-CoV-2 mRNA Vaccine Elicits Sustained T Cell Responses Against the Omicron Variant in Adolescents
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Choi Su-Jin
Kim Sang-Hoon
Han Mi-Seon
Yoon Yoon-Sun
Kim Yun-Kyung
Cho Hye-Kyung
Yun Ki-Wook
Song Seung-Ha
Ahn Bin
Kim Ye-Kyung
Choi Sung-Hwan
Choe Young-June
Lim Hee-Ji
Choi Eun-Bee
Kim Kwang-Wook
Hyeon Seok-Hwan
Lim Hye-Jung
Kim Byung-Chul
Lee Yoo-Kyoung
Choi Eun-Hwa
Shin Eui-Cheol
Lee Hyun-Ju
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Abstract
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Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been acknowledged as an effective mean of preventing infection and hospitalization. However, the emergence of highly transmissible SARS-CoV-2 variants of concern (VOCs) has led to substantial increase in infections among children and adolescents. Vaccine-induced immunity and longevity have not been well defined in this population. Therefore, we aimed to analyze humoral and cellular immune responses against ancestral and SARS-CoV-2 variants after two shots of the BNT162b2 vaccine in healthy adolescents. Although vaccination induced a robust increase of spike-specific binding Abs and neutralizing Abs against the ancestral and SARS-CoV-2 variants, the neutralizing activity against the Omicron variant was significantly low. On the contrary, vaccine-induced memory CD4+ T cells exhibited substantial responses against both ancestral and Omicron spike proteins. Notably, CD4+ T cell responses against both ancestral and Omicron strains were preserved at 3 months after two shots of the BNT162b2 vaccine without waning. Polyfunctionality of vaccine-induced memory T cells was also preserved in response to Omicron spike protein. The present findings characterize the protective immunity of vaccination for adolescents in the era of continuous emergence of variants/subvariants.
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KEYWORD
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SARS-CoV-2, SARS-CoV-2 variants, COVID-19 vaccines, Adolescent
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